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Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens.

Abstract：

:A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6alpha-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI(50) 2-5 microg/mL.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Son KH,Oh HM,Choi SK,Han DC,Kwon BM

doi

10.1016/j.bmcl.2005.02.057

subject

Has Abstract

pub_date

2005-04-15 00:00:00

pages

2019-21

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00231-3

journal_volume

15

pub_type

杂志文章

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