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Fluorescent metal ion indicators based on benzoannelated crown systems: a green fluorescent indicator for intracellular sodium ions.

Abstract：

:The synthesis and metal binding properties of cation-sensitive fluorescent indicators intended for biological applications are described. The increase of the crown ether ring size enhances the affinity for larger cations, but weakens the fluorescent response and selectivity. A compound having a 15-crown-5 chelator directly attached to a 2,7-difluoroxanthenone fluorophore loads into live cells and responds to sodium ion concentration changes with large fluorescence increases in the visible wavelength range.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Martin VV,Rothe A,Gee KR

doi

10.1016/j.bmcl.2005.02.017

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

1851-5

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00186-1

journal_volume

15

pub_type

杂志文章

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