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A naturally occurring brominated furanone covalently modifies and inactivates LuxS.

Abstract：

:Halogenated furanones, a group of natural products initially isolated from marine red algae, are known to inhibit bacterial biofilm formation, swarming, and quorum sensing. However, their molecular targets and the precise mode of action remain elusive. Herein, we show that a naturally occurring brominated furanone covalently modifies and inactivates LuxS (S-ribosylhomocysteine lyase, EC 4.4.1.21), the enzyme which produces autoinducer-2 (AI-2).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Zang T,Lee BW,Cannon LM,Ritter KA,Dai S,Ren D,Wood TK,Zhou ZS

doi

10.1016/j.bmcl.2009.08.095

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

6200-4

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01240-2

journal_volume

19

pub_type

杂志文章

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