Remarkably fast and selective aromatization of Hantzsch esters with MoOCl4 and MoCl5: a chemical model for possible biologically relevant properties of molybdenum-containing enzymes.

Abstract:

:Mo(VI) and Mo(V) salts both react selectively with Hantzsch esters to produce substitute pyridines in good-to-excellent yield (75-99%). The remarkable reactivity and selectivity of MoOCl(4) under reflux of acetonitrile and MoCl(5) in dichloromethane at room temperature encouraged us to propose that molybdenum-containing enzymes (such as xanthine or aldehyde oxidase) also participate to some degree in the metabolism of 1,4-dihydropyridine drugs in the liver analogous to NADH in the respiratory chain.

journal_name

Bioorg Med Chem Lett

authors

Litvić M,Regović M,Smic K,Lovrić M,Filipan-Litvić M

doi

10.1016/j.bmcl.2012.04.043

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

3676-81

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00482-9

journal_volume

22

pub_type

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