Abstract:
:Mo(VI) and Mo(V) salts both react selectively with Hantzsch esters to produce substitute pyridines in good-to-excellent yield (75-99%). The remarkable reactivity and selectivity of MoOCl(4) under reflux of acetonitrile and MoCl(5) in dichloromethane at room temperature encouraged us to propose that molybdenum-containing enzymes (such as xanthine or aldehyde oxidase) also participate to some degree in the metabolism of 1,4-dihydropyridine drugs in the liver analogous to NADH in the respiratory chain.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Litvić M,Regović M,Smic K,Lovrić M,Filipan-Litvić Mdoi
10.1016/j.bmcl.2012.04.043subject
Has Abstractpub_date
2012-06-01 00:00:00pages
3676-81issue
11eissn
0960-894Xissn
1464-3405pii
S0960-894X(12)00482-9journal_volume
22pub_type
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