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Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.

Abstract：

:Novel analogues of the angiotensin I-converting enzyme (ACE) inhibitor keto-ACE were synthesized via a facile Horner-Emmons olefination of a phosphonoketone precursor with ethyl glyoxylate. Introduction of a bulky aromatic tryptophan at the P(2)(') position of keto-ACE resulted in a significant increase in C-domain-selectivity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Nchinda AT,Chibale K,Redelinghuys P,Sturrock ED

doi

10.1016/j.bmcl.2006.06.003

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

4612-5

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00670-6

journal_volume

16

pub_type

杂志文章

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