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Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists.

Abstract：

:A series of novel 1,3-benzodiazapine based D1 antagonists was designed according to the understanding of pharmacophore models derived from SCH 23390 (1b), a potent and selective D1 antagonist. The new design features an achiral cyclic-amidine that maintains desired basicity. Solid phase synthesis was developed for SAR development of the novel dopamine antagonists.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Zhu Z,Sun ZY,Ye Y,McKittrick B,Greenlee W,Czarniecki M,Fawzi A,Zhang H,Lachowicz JE

doi

10.1016/j.bmcl.2009.07.012

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

5218-21

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00957-3

journal_volume

19

pub_type

杂志文章

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