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Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles.

Abstract：

:The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one, 3-[(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wood ER,Kuyper L,Petrov KG,Hunter RN 3rd,Harris PA,Lackey K

doi

10.1016/j.bmcl.2003.12.002

subject

Has Abstract

pub_date

2004-02-23 00:00:00

pages

953-7

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960894X03012848

journal_volume

14

pub_type

杂志文章

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