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Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents.

Abstract：

:Naphthalimide-derived azoles as a new type of antimicrobial agents were synthesized and evaluated for their efficiency in vitro against eight bacteria and two fungi by two fold serial dilution technique. Most title compounds exhibited good antimicrobial potency with low MIC values ranging from 1 to 16μg/mL. Notably, some synthesized compounds displayed comparable or even better antibacterial and antifungal activities against some tested strains than the reference drugs Orbifloxacin, Chloromycin and Fluconazole, respectively.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Zhang YY,Zhou CH

doi

10.1016/j.bmcl.2011.05.042

subject

Has Abstract

pub_date

2011-07-15 00:00:00

pages

4349-52

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)00671-8

journal_volume

21

pub_type

杂志文章

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