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Lobophorins A and B, new antiinflammatory macrolides produced by a tropical marine bacterium.

Abstract：

:Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent inhibitors of topical PMA-induced edema in the mouse ear assay when administered either topically or IP.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Jiang ZD,Jensen PR,Fenical W

doi

10.1016/s0960-894x(99)00337-6

subject

Has Abstract

pub_date

1999-07-19 00:00:00

pages

2003-6

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960894X99003376

journal_volume

9

pub_type

杂志文章

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