Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs.

Abstract:

:The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).

journal_name

Bioorg Med Chem Lett

authors

Coughlin JE,Padmanabhan S,Zhang G,Kirk CJ,Govardhan CP,Korba BE,O'Loughlin K,Green CE,Mirsalis J,Morrey JD,Iyer RP

doi

10.1016/j.bmcl.2010.01.010

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

1783-6

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)00012-0

journal_volume

20

pub_type

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