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Poly(ADP-ribose): From chemical synthesis to drug design.

Abstract：

:Poly(ADP-ribose) (PAR) is an important biopolymer, which is involved in various life processes such as DNA repair and replication, modulation of chromatin structure, transcription, cell differentiation, and in pathogenesis of various diseases such as cancer, diabetes, ischemia and inflammations. PAR is the most electronegative biopolymer and this property is essential for its binding with a wide range of proteins. Understanding of PAR functions in cell on molecular level requires chemical synthesis of regular PAR oligomers. Recently developed methodologies for chemical synthesis of PAR oligomers, will facilitate the study of various cellular processes, involving PAR.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Drenichev MS,Mikhailov SN

doi

10.1016/j.bmcl.2016.06.008

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

3395-403

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(16)30619-9

journal_volume

26

pub_type

杂志文章,评审

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