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Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups.

Abstract：

:A series of leinamycin derivatives were synthesized and evaluated for antitumor activity. Modifications at C-8 and C-9 positions revealed a broad structure-activity relationship in vitro and some derivatives showed potent antiproliferative activity against HeLa S3 cells.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kanda Y,Ashizawa T,Saitoh Y,Saito H,Gomi K,Okabe M

doi

10.1016/s0960-894x(98)00133-4

subject

Has Abstract

pub_date

1998-04-21 00:00:00

pages

909-12

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960894X98001334

journal_volume

8

pub_type

杂志文章

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