Abstract:
:The continual increase in drug resistance; the lack of new chemotherapeutic agents; the toxicity of existing agents and the increasing morbidity with HIV co-infection mean the search for new antileishmanial agents has never been more urgent. We have identified the benzodiazepines as a structural class for antileishmanial hit optimisation, and demonstrated that their in vitro activity is comparable with the clinically used drug, sodium stibogluconate, and that the compounds are not toxic to macrophages.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Clark RL,Carter KC,Mullen AB,Coxon GD,Owusu-Dapaah G,McFarlane E,Duong Thi MD,Grant MH,Tettey JN,Mackay SPdoi
10.1016/j.bmcl.2006.11.004subject
Has Abstractpub_date
2007-02-01 00:00:00pages
624-7issue
3eissn
0960-894Xissn
1464-3405pii
S0960-894X(06)01290-Xjournal_volume
17pub_type
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