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Structural hybridization as a facile approach to new drug candidates.

Abstract：

:Structural hybridization of preclinically and clinically validated pharmacologically active molecules has emerged as a promising tool to develop new generations of safe and highly efficient drug candidates against various diseases including microbial infections, virus infections and cancer. Strategies of drug-drug combinations have been adopted to generate hybrid conjugates of many clinically used drugs, designed to address inherent problems associated with these drugs. Thus, the design of hybrids was aimed to achieve higher efficacy through possible multi-target interactions, selective delivery of the drug to the site of action with the aim to improve bioavailability, alleviate toxicity and circumvent drug resistances. In this review article, we summarize the progress made in recent years in the rapidly growing field of drug discovery, focusing on the rationality of the hybrid design with particular emphasis on the linker architecture, which plays a crucial role in the overall success of a hybrid drug.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Sampath Kumar HM,Herrmann L,Tsogoeva SB

doi

10.1016/j.bmcl.2020.127514

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

127514

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(20)30625-9

journal_volume

30

pub_type

杂志文章,评审

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