Abstract:
:A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity. The antimalarial data for this series suggests that growth inhibition of the W2 strain of Plasmodium falciparum can be imparted by the introduction of a methoxy group ortho to the acetylenic group. Most compounds were more active against non-replicating than replicating cultures of Mycobacterium tuberculosis H(37)Rv, an unusual pattern with respect to existing anti-TB agents.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Hans RH,Guantai EM,Lategan C,Smith PJ,Wan B,Franzblau SG,Gut J,Rosenthal PJ,Chibale Kdoi
10.1016/j.bmcl.2009.12.062subject
Has Abstractpub_date
2010-02-01 00:00:00pages
942-4issue
3eissn
0960-894Xissn
1464-3405pii
S0960-894X(09)01785-5journal_volume
20pub_type
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journal_title:Bioorganic & medicinal chemistry letters
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