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Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase.

Abstract：

:Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in T(m) value of the G-quadruplex was associated with telomerase inhibition in vitro.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Alberti P,Schmitt P,Nguyen CH,Rivalle C,Hoarau M,Grierson DS,Mergny JL

doi

10.1016/s0960-894x(02)00080-x

subject

Has Abstract

pub_date

2002-04-08 00:00:00

pages

1071-4

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960894X0200080X

journal_volume

12

pub_type

杂志文章

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