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Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.

Abstract：

:Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a large number of derivatives enabling the evaluation of the effects of different functional groups on biological activities. In this Letter, we report the successful synthesis of a series of novel prenylated chalcones via Claisen-Schmidt condensation and the evaluation of their effect on the viability of the Trypanosomatidae parasites Leishmania amazonensis, Leishmania infantum and Trypanosoma cruzi.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Passalacqua TG,Dutra LA,de Almeida L,Velásquez AM,Torres FA,Yamasaki PR,dos Santos MB,Regasini LO,Michels PA,Bolzani Vda S,Graminha MA

doi

10.1016/j.bmcl.2015.05.072

subject

Has Abstract

pub_date

2015-08-15 00:00:00

pages

3342-5

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)00546-6

journal_volume

25

pub_type

杂志文章

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