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Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities.

Abstract：

:Eight monosaccharide analogs of the potent antitumor OSW saponins (2-9) were synthesized. One analog, 2-O-acetyl-alpha-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC(50)=0.078microM) comparable to that of the disaccharide derivative (1).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Tang P,Mamdani F,Hu X,Liu JO,Yu B

doi

10.1016/j.bmcl.2006.11.032

subject

Has Abstract

pub_date

2007-02-15 00:00:00

pages

1003-7

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)01325-4

journal_volume

17

pub_type

杂志文章

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