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Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit.

Abstract：

:A series of new imines and amines have been synthesized by condensation of 1H-3-ferrocenyl-1-phenylpyrazole-4-carboxaldehyde with the corresponding amines, followed by reduction with sodium borohydride. The synthesized compounds have been screened for their in vitro antimicrobial activity against 11 bacteria and three fungal/yeast strains, using disc diffusion and broth microdilution susceptibility assays. They have shown a wide range of activities, from completely inactive to the highly active compounds.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Damljanović I,Vukićević M,Radulović N,Palić R,Ellmerer E,Ratković Z,Joksović MD,Vukićević RD

doi

10.1016/j.bmcl.2009.01.006

subject

Has Abstract

pub_date

2009-02-15 00:00:00

pages

1093-6

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00011-0

journal_volume

19

pub_type

杂志文章

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