Structural basis of the dynamic mechanism of ligand binding to cyclooxygenase.

Abstract:

:Molecular modeling studies performed on the two cyclooxygenase (COX) isozymes suggest that the cavity at the mouth of the active site on the membrane domain that may act as an actual binding site of COX ligands. Actual docking of different inhibitors at this site provides a structural basis to explain the dynamics of COX inhibition.

journal_name

Bioorg Med Chem Lett

authors

Llorens O,Perez JJ,Palomer A,Mauleon D

doi

10.1016/s0960-894x(99)00481-3

subject

Has Abstract

pub_date

1999-10-04 00:00:00

pages

2779-84

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960894X99004813

journal_volume

9

pub_type

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