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Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targeting.

Abstract：

:Multivalent interactions play an essential role in molecular recognition in living systems. These effects were employed to target tumor cells using albumin clusters bearing ∼10 molecules of asparagine-linked glycans (N-glycans). Noninvasive near-infrared fluorescence imaging clearly revealed A431 tumors implanted in BALB/cA-nu/nu mice after 1h in an N-glycan structure-dependent manner, thereby demonstrating the efficient use of glycan multivalency effects for tumor targeting in vivo.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ogura A,Tahara T,Nozaki S,Onoe H,Kurbangalieva A,Watanabe Y,Tanaka K

doi

10.1016/j.bmcl.2016.03.046

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

2251-4

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(16)30266-9

journal_volume

26

pub_type

杂志文章

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