Abstract:
:Human isoprenylcysteine carboxyl methyltransferase (hIcmt) is a promising anticancer target as it is important for the post-translational modification of oncogenic Ras proteins. We herein report the synthesis and biochemical activity of 41 farnesyl-cysteine based analogs versus hIcmt. We have demonstrated that the amide linkage of a hIcmt substrate can be replaced by a sulfonamide bond to achieve hIcmt inhibition. The most potent sulfonamide-modified farnesyl cysteine analog was 6ag with an IC(50) of 8.8±0.5 μM for hIcmt.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Majmudar JD,Hahne K,Hrycyna CA,Gibbs RAdoi
10.1016/j.bmcl.2011.01.078subject
Has Abstractpub_date
2011-05-01 00:00:00pages
2616-20issue
9eissn
0960-894Xissn
1464-3405pii
S0960-894X(11)00101-6journal_volume
21pub_type
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