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Inhibition of HIV-1 infection by synthetic peptide analogues derived from the NH(2)-Terminal extracellular region of GPR1.

Abstract：

:Several shortened peptide analogues of the N-terminal domain of GPR1, an orphan G protein-coupled receptor (GPCR), were prepared and their anti-HIV-1 activities were evaluated. Some of the prepared compounds, especially sulfated derivatives, showed potent inhibitory activity against a broad range of HIV-1, including T cell-tropic, dual cell-tropic and brain-derived (BT) cell-tropic HIV-1 strains.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ikeda K,Konishi K,Sato M,Hoshino H,Tanaka K

doi

10.1016/s0960-894x(01)00503-0

subject

Has Abstract

pub_date

2001-10-08 00:00:00

pages

2607-9

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960894X01005030

journal_volume

11

pub_type

杂志文章

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