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Synthesis and photophysical properties of new SNARF derivatives as dual emission pH sensors.

Abstract：

:We report the synthesis and properties of two new seminaphthorhodafluor (SNARF) derivatives, SNARF-F and SNARF-Cl. Both these derivatives exhibit typical red shifts of absorption and fluorescence, and higher cell permeability as compared to traditional SNARF, while the pH-dependent dual-emission characteristics are well retained. In particular, the lower pK(a) (7.38) of SNARF-F makes it more suitable than traditional SNARF derivatives for intracellular applications.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Nakata E,Nazumi Y,Yukimachi Y,Uto Y,Maezawa H,Hashimoto T,Okamoto Y,Hori H

doi

10.1016/j.bmcl.2011.01.105

subject

Has Abstract

pub_date

2011-03-15 00:00:00

pages

1663-6

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)00128-4

journal_volume

21

pub_type

杂志文章

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