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The contribution of adenines in the catalytic core of 10-23 DNAzyme improved by the 6-amino group modifications.

Abstract：

:In the catalytic core of 10-23 DNAzyme, its five adenine residues are moderate conservative, but with highly conserved functional groups like 6-amino group and 7-nitrogen atom. It is this critical conservation that these two groups could be modified for better contribution. With 2'-deoxyadenosine analogues, several functional groups were introduced at the 6-amino group of the five adenine residues. 3-Aminopropyl substituent at 6-amino group of A15 resulted in a five-fold increase of kobs. More efficient DNAzymes are expected by delicate design of the linkage and the external functional groups for this 6-amino group of A15. With this modification approach, other functional groups or residues could be optimized for 10-23 DNAzyme.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Zhu J,Li Z,Wang Q,Liu Y,He J

doi

10.1016/j.bmcl.2016.07.076

subject

Has Abstract

pub_date

2016-09-15 00:00:00

pages

4462-4465

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(16)30804-6

journal_volume

26

pub_type

杂志文章

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