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Synthesis of 1,6,7,8-tetrahydro-naphtho[2,3-d]-azepino[4,5-b]indole-9,14-diones and their inhibitory effects on pro-inflammatory cytokines.

Abstract：

:A rapid route to a series of naphthoquinone-fused indole derivatives via irradiation in a modified commercial domestic microwave is reported. The desired products were produced in high yields and short reaction times. The naphthoquinone-fused indole derivatives were evaluated for their pro-inflammatory cytokines responses using lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. The results showed that most of the tested compounds inhibit the production of nitric oxide (NO), prostaglandin (PG)E(2), tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta in RAW264.7 cells treated with LPS.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Phutdhawong WS,Ruensamran W,Phutdhawong W,Taechowisan T

doi

10.1016/j.bmcl.2009.07.154

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

5753-6

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01125-1

journal_volume

19

pub_type

杂志文章

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