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UV spectroscopy study on complexes of phosphonate ApA analogs with poly(U): promising step in prediction of oligonucleotide analog properties?

Abstract：

:The isopolar nonisosteric phosphonate analogs of ApA differing in the position of extra methylene group introduced into the sugar-phosphate backbone, featuring both possible 2',5'- and 3',5'- pairs as well as their conformationally restricted congeners, were investigated for their ability to form complexes with polyU. The results may lead to the specification of candidates for synthesis of novel oligonucleotides.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Pressová M,Endová M,Toĉík Z,Liboska R,Rosenberg I

doi

10.1016/s0960-894x(98)00190-5

subject

Has Abstract

pub_date

1998-05-19 00:00:00

pages

1225-30

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960894X98001905

journal_volume

8

pub_type

杂志文章

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