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Synthesis and preliminary evaluation of mono-[123I]iodohypericin monocarboxylic acid as a necrosis avid imaging agent.

Abstract：

:Hypericin monocarboxylic acid was synthesized in an overall yield of 25% in four steps and radiolabelled with iodine-123 in good yield (>75%). The resulting mono-[(123)I]iodohypericin monocarboxylic acid was evaluated in normal mice and in rats with ethanol induced liver necrosis. In this model, tracer concentration in necrotic liver tissue was 14 times higher than in the viable liver tissue as quantified by autoradiography at 24h post injection. The results indicate the feasibility of visualization of necrotic tissue with the novel tracer.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Fonge H,Jin L,Wang H,Ni Y,Bormans G,Verbruggen A

doi

10.1016/j.bmcl.2007.04.083

subject

Has Abstract

pub_date

2007-07-15 00:00:00

pages

4001-5

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00516-1

journal_volume

17

pub_type

杂志文章

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