(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.

Abstract:

:A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.

journal_name

Bioorg Med Chem Lett

authors

Gasparini F,Inderbitzin W,Francotte E,Lecis G,Richert P,Dragic Z,Kuhn R,Flor PJ

doi

10.1016/s0960-894x(00)00197-9

subject

Has Abstract

pub_date

2000-06-05 00:00:00

pages

1241-4

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(00)00197-9

journal_volume

10

pub_type

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