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Simultaneous detection of alkaline phosphatase and beta-galactosidase activity using SERRS.

Abstract：

:Surface enhanced resonance Raman scattering (SERRS) is an alternative to fluorescence for use in bioanalysis however due to the different optical mechanism it requires specifically designed reporters. Recently we have reported the use of 8-hydroxyquinolinyl azo dyes and their ester derivatives as reporters of lipase activity using SERRS. Acylation of the 8-hydroxy moiety significantly reduces surface enhancement of the Raman response and subsequent lipase catalysed ester hydrolysis enables the analyte to bind to silver nanoparticles, thus providing surface enhancement and the SERRS signal is 'switched on'. By following this principle, phosphorylated and galactosylated analogues of 8-hydroxyquinolinylazo dyes were prepared and shown to act as reporters of enzymatic activity for alkaline phosphatase and beta-galactosidase respectively when using SERRS.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ingram A,Moore BD,Graham D

doi

10.1016/j.bmcl.2009.02.030

subject

Has Abstract

pub_date

2009-03-15 00:00:00

pages

1569-71

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00184-X

journal_volume

19

pub_type

杂志文章

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