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Array synthesis of novel lipodepsipeptide.

Abstract：

:Synthetic array technology was utilized to rapidly synthesize and analyze a diverse set of reductive alkylation analogues of daptomycin. Analysis of the array suggested the use of polar functionality such as sulfonamides or amide or polar spaces such as piperazine would beneficially affect activity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Siedlecki J,Hill J,Parr I,Yu X,Morytko M,Zhang Y,Silverman J,Controneo N,Laganas V,Li T,Li J,Keith D,Shimer G,Finn J

doi

10.1016/j.bmcl.2003.07.025

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

4245-9

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960894X03008850

journal_volume

13

pub_type

杂志文章

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