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Alpha-keto amides as inhibitors of histone deacetylase.

Abstract：

:Alpha-keto ester and amides were found to be potent inhibitors of histone deacetylase. Nanomolar inhibitors against the isolated enzyme and sub-micromolar inhibitors of cellular proliferation were obtained. The alpha-keto amide 30 also exhibited significant anti-tumor effects in an in vivo tumor model.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wada CK,Frey RR,Ji Z,Curtin ML,Garland RB,Holms JH,Li J,Pease LJ,Guo J,Glaser KB,Marcotte PA,Richardson PL,Murphy SS,Bouska JJ,Tapang P,Magoc TJ,Albert DH,Davidsen SK,Michaelides MR

doi

10.1016/s0960-894x(03)00685-1

subject

Has Abstract

pub_date

2003-10-06 00:00:00

pages

3331-5

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960894X03006851

journal_volume

13

pub_type

杂志文章

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