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New strigolactone mimics: structure-activity relationship and mode of action as germinating stimulants for parasitic weeds.

Abstract：

:Strigolactones (SLs) are new plant hormones with varies important bio-functions. This Letter deals with germination of seeds of parasitic weeds. Natural SLs have a too complex structure for synthesis. Therefore, there is an active search for SL analogues and mimics with a simpler structure with retention of activity. SL analogues all contain the D-ring connected with an enone moiety through an enol ether unit. A new mechanism for the hydrolysis SL analogues involving bidentate bound water and an α,β-hydrolase with a Ser-His-Asp catalytic triad has been proposed. Newly discovered SL mimics only have the D-ring with an appropriate leaving group at C-5. A mode of action for SL mimics was proposed for which now supporting evidence is provided. As predicted an extra methyl group at C-4 of the D-ring blocks the germination of seeds of parasitic weeds.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Zwanenburg B,Nayak SK,Charnikhova TV,Bouwmeester HJ

doi

10.1016/j.bmcl.2013.07.004

subject

Has Abstract

pub_date

2013-09-15 00:00:00

pages

5182-6

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)00838-X

journal_volume

23

pub_type

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