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Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: design of ICAM-1 cyclic peptides.

Abstract：

:In this work, we have designed cyclic peptides (cIBL, cIBR, cIBC, CH4 and CH7) derived from the parent IB peptide (ICAM-1(1-21)) that are inhibitors of ICAM-1/LFA-1-mediated T-cell adhesion to Caco-2 cell monolayers. Cyclic peptide cIBR has the best activity of any of the peptides evaluated. The active ICAM-1 peptides have a common Pro-Arg-Gly sequence that may be important for binding to LFA-1.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Anderson ME,Yakovleva T,Hu Y,Siahaan TJ

doi

10.1016/j.bmcl.2003.09.100

subject

Has Abstract

pub_date

2004-03-22 00:00:00

pages

1399-402

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960894X04000605

journal_volume

14

pub_type

杂志文章

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