N-DEVD-N'-morpholinecarbonyl-rhodamine 110: novel caspase-3 fluorogenic substrates for cell-based apoptosis assay.

Abstract:

:A novel caspase-3 substrate N-Ac-DEVD-N'-MC-R110, which is a fluorogenic substrate cleavable in a single step, has been prepared. It has a significantly higher enzyme turnover rate and sensitivity for detecting caspase-3 activity both in solution and living cells than existing fluorogenic substrates.

journal_name

Bioorg Med Chem Lett

authors

Wang ZQ,Liao J,Diwu Z

doi

10.1016/j.bmcl.2005.02.081

subject

Has Abstract

pub_date

2005-05-02 00:00:00

pages

2335-8

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00274-X

journal_volume

15

pub_type

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