A synthesis of 3-deoxydihydrolycoricidine: refinement of a structurally minimum pancratistatin pharmacophore.

Abstract:

:The synthesis of 3-deoxydihydrolycoricidine, a key element toward elucidation of the pancratistatin anticancer pharmacophore, is described. Biological evaluation of this compound showed it to be significantly less active against tumor cells than pancratistatin. In addition to those features previously identified, the requirement of a 2,3,4-triol functionalized ring-C is now definitely established as the minimum pharmacophoric element for potent anticancer activity.

journal_name

Bioorg Med Chem Lett

authors

McNulty J,Larichev V,Pandey S

doi

10.1016/j.bmcl.2005.08.024

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

5315-8

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)01042-5

journal_volume

15

pub_type

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