New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3.

Abstract:

:Two nemadectin congeners 1 and 2 were isolated from the fermentation broth of a mutant strain (Y-3) of Streptomyces microflavus neau3. Their structures were determined on the basis of extensive spectroscopic analysis and comparison with data from the literature. Compound 2 possessed a 5-membered ring lactone that is unprecedented among known milbemycins and avermectins. Both compounds 1 and 2 exhibited potent acaricidal activity and nematocidal activity. Especially, compound 2 demonstrated impressive acaricidal activity against adult mites with an IC50 of 2.3±0.9 μg/mL and mite eggs with an IC50 of 17.5±2.1 μg/mL and nematocidal activity against Caenorhabditis elegans with an IC50 of 0.7±0.2 μg/mL, which are higher than those of nemadectin and the known commercial acaricide and nematocide milbemycin A3/A4.

journal_name

Bioorg Med Chem Lett

authors

Yang LY,Wang JD,Zhang J,Xue CY,Zhang H,Wang XJ,Xiang WS

doi

10.1016/j.bmcl.2013.08.002

subject

Has Abstract

pub_date

2013-10-15 00:00:00

pages

5710-3

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)00931-1

journal_volume

23

pub_type

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