Abstract:
:Two nemadectin congeners 1 and 2 were isolated from the fermentation broth of a mutant strain (Y-3) of Streptomyces microflavus neau3. Their structures were determined on the basis of extensive spectroscopic analysis and comparison with data from the literature. Compound 2 possessed a 5-membered ring lactone that is unprecedented among known milbemycins and avermectins. Both compounds 1 and 2 exhibited potent acaricidal activity and nematocidal activity. Especially, compound 2 demonstrated impressive acaricidal activity against adult mites with an IC50 of 2.3±0.9 μg/mL and mite eggs with an IC50 of 17.5±2.1 μg/mL and nematocidal activity against Caenorhabditis elegans with an IC50 of 0.7±0.2 μg/mL, which are higher than those of nemadectin and the known commercial acaricide and nematocide milbemycin A3/A4.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Yang LY,Wang JD,Zhang J,Xue CY,Zhang H,Wang XJ,Xiang WSdoi
10.1016/j.bmcl.2013.08.002subject
Has Abstractpub_date
2013-10-15 00:00:00pages
5710-3issue
20eissn
0960-894Xissn
1464-3405pii
S0960-894X(13)00931-1journal_volume
23pub_type
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