Abstract:
:A novel series of thiazolone-acylsulfonamides were designed as HCV NS5B polymerase allosteric inhibitors. The structure based drug designs (SBDD) were guided by docking results that revealed the potential to explore an additional pocket in the allosteric site. In particular, the designed molecules contain moieties of previously described thiazolone and a newly designed acylsulfonamide linker that is in turn connected with a substituted aromatic ring. The selected compounds were synthesized and demonstrated low muM activity. The X-ray complex structure was determined at a 2.2A resolution and converged with the SBDD principle.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Yan S,Appleby T,Larson G,Wu JZ,Hamatake RK,Hong Z,Yao Ndoi
10.1016/j.bmcl.2007.01.024subject
Has Abstractpub_date
2007-04-01 00:00:00pages
1991-5issue
7eissn
0960-894Xissn
1464-3405pii
S0960-894X(07)00072-8journal_volume
17pub_type
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