Abstract:
:1,5-Diazaanthraquinone derivatives were synthesized employing single and double hetero Diels-Alder strategies. Their in vitro antitumour activity was assayed using three cell lines. Some of these compounds, specially those bearing methyl or ethyl groups at the C-3,7 positions or chloro at C-4 and methyl at C-7, showed IC(50) values in the 10(-8)M range for human lung carcinoma and human melanoma, which makes them attractive candidates for further development as anticancer agents.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Avendaño C,Pérez JM,Blanco Mdel M,de la Fuente JA,Manzanaro S,Vicent MJ,Martín MJ,Salvador-Tormo N,Menéndez JCdoi
10.1016/j.bmcl.2004.05.055subject
Has Abstractpub_date
2004-08-02 00:00:00pages
3929-32issue
15eissn
0960-894Xissn
1464-3405pii
S0960894X0400705Xjournal_volume
14pub_type
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