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Synthesis and structure-activity relationships of 1,5-diazaanthraquinones as antitumour compounds.

Abstract：

:1,5-Diazaanthraquinone derivatives were synthesized employing single and double hetero Diels-Alder strategies. Their in vitro antitumour activity was assayed using three cell lines. Some of these compounds, specially those bearing methyl or ethyl groups at the C-3,7 positions or chloro at C-4 and methyl at C-7, showed IC(50) values in the 10(-8)M range for human lung carcinoma and human melanoma, which makes them attractive candidates for further development as anticancer agents.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Avendaño C,Pérez JM,Blanco Mdel M,de la Fuente JA,Manzanaro S,Vicent MJ,Martín MJ,Salvador-Tormo N,Menéndez JC

doi

10.1016/j.bmcl.2004.05.055

subject

Has Abstract

pub_date

2004-08-02 00:00:00

pages

3929-32

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960894X0400705X

journal_volume

14

pub_type

杂志文章

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