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Isolation, semi-synthesis and bio-evaluation of spatane derivatives from the brown algae Stoechospermum marginatum.

Abstract：

:A comprehensive investigation of chemical constituents from brown algae Stoechospermum marginatum yielded ten known spatane compounds (1-10). To develop the compound libraries on these scaffolds, a series of semi synthetic derivatives was prepared (1a-1d, 2a, 4a, 11 and 12) and investigated for their anti-microbial and anticancer activities. The results indicated that compounds 2a, 4, 1b and 4a exhibited potent cytotoxic activities against B16F10 cancer cell line with IC50 values of 3.28, 3.45, 3.62 and 4.11 μg/ml respectively, which are comparable to the standard drug (etoposide IC50=4.12 μg/ml). In addition, 4 and 1b were also manifested potent antimicrobial activities against tested bacterial and fungal strains. This is the first Letter on the synthesis and biological activities of these novel derivatives.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Chinnababu B,Purushotham Reddy S,Sankara Rao P,Loka Reddy V,Sudheer Kumar B,Rao JV,Prakasham RS,Suresh Babu K

doi

10.1016/j.bmcl.2015.04.061

subject

Has Abstract

pub_date

2015-06-15 00:00:00

pages

2479-83

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)00393-5

journal_volume

25

pub_type

杂志文章

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