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Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors.

Abstract：

:Amino-1,2,5-trideoxy-2,5-imino-D-mannitol was fluorescently tagged by reaction with dansyl chloride at N-1 or by attachment of a dansyl amide bearing spacer to this centre. Compounds obtained are highly potent inhibitors of beta-glucosidase exhibiting Ki values in the single figure nanomolar range. The 1-N-dansyl substituted inhibitor was successfully exploited for binding studies with beta-glucosidase from Agrobacterium sp. employing fluorescence spectrometric methods.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hermetter A,Scholze H,Stütz AE,Withers SG,Wrodnigg TM

doi

10.1016/s0960-894x(01)00209-8

subject

Has Abstract

pub_date

2001-05-21 00:00:00

pages

1339-42

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960894X01002098

journal_volume

11

pub_type

杂志文章

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