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[(13)C3,(15)N1]-labeled isodesmosine: A potential internal standard for LC-MS/MS analysis of desmosines in elastin degradation.

Abstract：

:Isodesmosine and desmosine are crosslinking amino acids that are present only in elastin. They are useful biomarkers for the degradation of elastin, which occurs during the progression of chronic obstructive pulmonary disease (COPD) and related diseases. This Letter describes the synthesis of [(13)C3,(15)N1]-labeled isodesmosine, using Chichibabin pyridine synthesis as a key reaction. The labeled isodesmosine is a potential internal standard for the quantitative LC-MS/MS analysis of desmosines in elastin degradation.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Tanigawa T,Komatsu A,Usuki T

doi

10.1016/j.bmcl.2015.03.084

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

2046-9

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)00300-5

journal_volume

25

pub_type

杂志文章

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