Evidence supporting the activity of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentafuranosylcytosine as a terminator in enzymatic DNA-chain elongation.

Abstract:

:To investigate the stability of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentafuranosylcytosine 3'-phosphoric acid, its thymidine ester was prepared via the phosphoramidite method using allyl protection for the phosphate function. This ester is stable under acidic conditions but extremely labile under basic conditions, decomposing with a cleavage of the internucleotide bond even at pH 7.3.

journal_name

Bioorg Med Chem Lett

authors

Hayakawa Y,Kawai R,Otsuki K,Kataoka M,Matsuda A

doi

10.1016/s0960-894x(98)00459-4

subject

Has Abstract

pub_date

1998-09-22 00:00:00

pages

2559-62

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960894X98004594

journal_volume

8

pub_type

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