Abstract:
:To investigate the stability of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentafuranosylcytosine 3'-phosphoric acid, its thymidine ester was prepared via the phosphoramidite method using allyl protection for the phosphate function. This ester is stable under acidic conditions but extremely labile under basic conditions, decomposing with a cleavage of the internucleotide bond even at pH 7.3.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Hayakawa Y,Kawai R,Otsuki K,Kataoka M,Matsuda Adoi
10.1016/s0960-894x(98)00459-4subject
Has Abstractpub_date
1998-09-22 00:00:00pages
2559-62issue
18eissn
0960-894Xissn
1464-3405pii
S0960894X98004594journal_volume
8pub_type
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