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A DOTA-peptide conjugate by copper-free click chemistry.

Abstract：

:Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Martin ME,Parameswarappa SG,O'Dorisio MS,Pigge FC,Schultz MK

doi

10.1016/j.bmcl.2010.06.111

subject

Has Abstract

pub_date

2010-08-15 00:00:00

pages

4805-7

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)00898-X

journal_volume

20

pub_type

杂志文章

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