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1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase.

Abstract：

:The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles is described. The compounds were tested for human placental aromatase inhibition in vitro, using [1beta-3H]-androstenedione as the substrate for the aromatase enzyme, the percentage inhibition and IC50 data is included.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Vinh TK,Ahmadi M,Delgado PO,Perez SF,Walters HM,Smith HJ,Nicholls PJ,Simons C

doi

10.1016/s0960-894x(99)00328-5

subject

Has Abstract

pub_date

1999-07-19 00:00:00

pages

2105-8

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960894X99003285

journal_volume

9

pub_type

杂志文章

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