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Multisubstituted indole-acrylonitrile hybrids as potential cytotoxic agents.

Abstract：

:A series of multisubstituted indole-acrylonitrile hybrids were designed, synthesized and evaluated for their potential cytotoxic activities. The bio-evaluation results indicated that some of the target compounds (such as 3a, 3f, 3k, 3n) exhibited good to moderate cytotoxic effect on HepG2, BCG-823, BEL-7402, and HL-7702 cell lines. Especially, the compounds 3a and 3k also exhibited high cytotoxic activities (3a, 19.38±3.38 μM; 3k, 15.43±3.54 μM) against the BEL-7402 cell line resistant to Taxol (>25μM) and 5-FU (>500 μM), which might be developed as novel lead scaffold for potential anticancer agents.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ke S,Yang Z,Zhang Z,Liang Y,Wang K,Liu M,Shi L

doi

10.1016/j.bmcl.2014.03.011

subject

Has Abstract

pub_date

2014-04-15 00:00:00

pages

1907-11

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00227-3

journal_volume

24

pub_type

杂志文章

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