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Aptazyme-based riboswitches as label-free and detector-free sensors for cofactors.

Abstract：

:We constructed a label-free and detector-free aptazyme-based riboswitch sensor for detecting the cofactor of the aptazyme. This riboswitch, which usually suppresses the gene expression with its anti-RBS sequence bound to the RBS of its own mRNA (OFF), activates the translation only when a cofactor is added to release the anti-RBS sequence from itself as a result of cofactor-induced self-cleavage by the aptazyme (ON). The rationally optimized one with beta-galactosidase as a reporter gene enabled us to detect the cofactor of the aptazyme visibly with high ON/OFF efficiency.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ogawa A,Maeda M

doi

10.1016/j.bmcl.2007.03.033

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

3156-60

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00324-1

journal_volume

17

pub_type

杂志文章

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