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Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.

Abstract：

:A series of N-8 substituted analogs based upon the spiropiperidine core of the original lead compound 1 was synthesized. This lead has been elaborated to compounds to give compounds 2 and 3 (R=H) that exhibited high NOP binding affinity as well as selectivity against other known opioid receptors. These two series have been further functionalized at the amido nitrogen. The synthesis and structure-activity relationship (SAR) of these and related compounds are discussed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Caldwell JP,Matasi JJ,Fernandez X,McLeod RL,Zhang H,Fawzi A,Tulshian DB

doi

10.1016/j.bmcl.2008.12.092

subject

Has Abstract

pub_date

2009-02-15 00:00:00

pages

1164-7

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01614-4

journal_volume

19

pub_type

杂志文章

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