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Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.

Abstract：

:Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC(50) values in the micromolar range.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Huang W,Li J,Zhang W,Zhou Y,Xie C,Luo Y,Li Y,Wang J,Li J,Lu W

doi

10.1016/j.bmcl.2005.12.080

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

1905-8

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00009-6

journal_volume

16

pub_type

杂志文章

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