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Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs).

Abstract：

:The CO-releasing properties of iron(0)tricarbonyl complexes bearing a 2-pyrone ligand have been evaluated. In this report, we demonstrate that the intrinsic stability of the (eta4-2-pyrone)Fe(CO)3 complex influences the extent and rate of CO release, which is affected by the presence of a halogen substituent on the 2-pyrone ring. The cell viability index has been highlighted for the active carbon monoxide-releasing molecules (CO-RMs), demonstrating that these complexes and related derivatives are a promising new class of compounds with potential therapeutic applications.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Fairlamb IJ,Duhme-Klair AK,Lynam JM,Moulton BE,O'Brien CT,Sawle P,Hammad J,Motterlini R

doi

10.1016/j.bmcl.2005.10.085

subject

Has Abstract

pub_date

2006-02-15 00:00:00

pages

995-8

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)01382-X

journal_volume

16

pub_type

杂志文章

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